Related Publications

  1. Single Spheroid Metabolomics: Optimizing Sample Preparation of Three-Dimensional Multicellular Tumor Spheroids. Rusz M, Rampler E, Keppler BK, Jakupec MA, Koellensperger G. Metabolites. 2019 Dec 14;9(12). pii: E304. doi: 10.3390/metabo9120304.
  2. Molecular response of Deinococcus radiodurans to simulated microgravity explored by proteometabolomic approach. Ott E, Fuchs FM, Moeller R, Hemmersbach R, Kawaguchi Y, Yamagishi A, Weckwerth W, Milojevic T. Sci Rep. 2019 Dec 5;9(1):18462. doi: 10.1038/s41598-019-54742-6.
  3. Coordination Complex Formation and Redox Properties of Kynurenic and Xanthurenic Acid Can Affect Brain Tissue Homeodynamics Kubicova L, Hadacek F, Bachmann G, Weckwerth W, Chobot V. Antioxidants (Basel). 2019 Oct 11;8(10). pii: E476. doi: 10.3390/antiox8100476.
  4. The Power of LC-MS Based Multiomics: Exploring Adipogenic Differentiation of Human Mesenchymal Stem/Stromal Cells. Rampler E, Egger D, Schoeny H, Rusz M, Pacheco MP, Marino G, Kasper C, Naegele T, Koellensperger G. Molecules. 2019 Oct 8;24(19). pii: E3615. doi: 10.3390/molecules24193615.
  5. Male Sterility in Maize after Transient Heat Stress during the Tetrad Stage of Pollen Development. Begcy K, Nosenko T, Zhou LZ, Fragner L, Weckwerth W, Dresselhaus T. Plant Physiol. 2019 Oct;181(2):683-700. doi: 10.1104/pp.19.00707.
  6. Resolving subcellular plant metabolism. Fürtauer L, Küstner L, Weckwerth W, Heyer AG, Nägele T.Plant J. 2019 Jul 30. doi: 10.1111/tpj.14472. [Epub ahead of print]
  7. Proteomic and Metabolomic Profiling of Deinococcus radiodurans Recovering After Exposure to Simulated Low Earth Orbit Vacuum Conditions. Ott E, Kawaguchi Y, Özgen N, Yamagishi A, Rabbow E, Rettberg P, Weckwerth W, Milojevic T. Front Microbiol. 2019 Apr 29;10:909. doi: 10.3389/fmicb.2019.00909.
  8. Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.Elgendy M, Cirò M, Hosseini A, Weiszmann J, Mazzarella L, Ferrari E, Cazzoli R, Curigliano G, DeCensi A, Bonanni B, Budillon A, Pelicci PG, Janssens V, Ogris M, Baccarini M, Lanfrancone L, Weckwerth W, Foiani M, Minucci S. Cancer Cell. 2019 Apr 10. pii: S1535-6108(19)30152-7. doi: 10.1016/j.ccell.2019.03.007. [Epub ahead of print]
  9. Resveratrol and other dietary polyphenols are inhibitors of estrogen metabolism in human breast cancer cells. Poschner S, Maier-Salamon A, Thalhammer T, Jäger W. J Steroid Biochem Mol Biol. 2019 Mar 6;190:11-18. doi: 10.1016/j.jsbmb.2019.03.001. [Epub ahead of print]
  10. Palbociclib and Fulvestrant Act in Synergy to Modulate Central Carbon Metabolism in Breast Cancer Cells. Warth B, Palermo A, Rattray NJW, Lee NV, Zhu Z, Hoang LT, Cai Y, Mazurek A, Dann S, VanArsdale T, Fantin VR, Shields D, Siuzdak G, Johnson CH. Metabolites. 2019 Jan 2;9(1). pii: E7. doi: 10.3390/metabo9010007.
  11. Quantitative Phosphoproteomic and System-Level Analysis of TOR Inhibition Unravel Distinct Organellar Acclimation in Chlamydomonas reinhardtii. Roustan V, Weckwerth W. Front Plant Sci. 2018 Nov 28;9:1590. doi: 10.3389/fpls.2018.01590. eCollection 2018.
  12. Eco-Metabolomics and Metabolic Modeling: Making the Leap From Model Systems in the Lab to Native Populations in the Field. Nagler M, Nägele T, Gilli C, Fragner L, Korte A, Platzer A, Farlow A, Nordborg M, Weckwerth W. Front Plant Sci. 2018 Nov 6;9:1556. doi: 10.3389/fpls.2018.01556. eCollection 2018.
  13. Monitoring Early Life Mycotoxin Exposures via LC-MS/MS Breast Milk Analysis. Braun D, Ezekiel CN, Abia WA, Wisgrill L, Degen GH, Turner PC, Marko D, Warth B. Anal Chem. 2018 Dec 18;90(24):14569-14577. doi: 10.1021/acs.analchem.8b04576. Epub 2018 Nov 30.

  14. Merging metabolomics and lipidomics into one analytical run. Schwaiger M, Schoeny H, El Abiead Y, Hermann G, Rampler E, Koellensperger G. Analyst. 2018 Nov 9. doi: 10.1039 [Epub ahead of print]

  15. Deciphering key proteins of oil palm (Elaeis guineensis Jacq.) fruit mesocarp development by proteomics and chemometrics. Hassan H, Amiruddin MD, Weckwerth W, Ramli US. Electrophoresis. 2018 Oct 29. doi: 10.1002 [Epub ahead of print]
  16. Microscopic and Proteomic Analysis of Dissected Developing Barley Endosperm Layers Reveals the Starchy Endosperm as Prominent Storage Tissue for ER-Derived Hordeins Alongside the Accumulation of Barley Protein Disulfide Isomerase (HvPDIL1-1). Roustan V, Roustan PJ, Weidinger M, Reipert S, Kapusi E, Shabrangy A, Stoger E, Weckwerth W, Ibl V. Front Plant Sci. 2018 Sep 10;9:1248. doi:  10.3389

  17. Vacuolar sucrose cleavage prevents limitation of cytosolic carbohydrate metabolism and stabilizes photosynthesis under abiotic stress.
    Weiszmann J, Fürtauer L, Weckwerth W, Nägele T. FEBS J. 2018 Sep 14. doi: 10.1111/febs.14656. [Epub ahead of print]
  18. Complementary intestinal mucosa and microbiota responses to caloric restriction.
    Duszka K, Ellero-Simatos S, Ow GS, Defernez M, Paramalingam E, Tett A, Ying S, König J, Narbad A, Kuznetsov VA, Guillou H, Wahli W. Sci Rep. 2018 Jul 27;8(1):11338. doi: 10.1038/s41598-018-29815-7.
  19. Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation.
    Poschner S, Maier-Salamon A, Zehl M, Wackerlig J, Dobusch D, Meshcheryakova A, Mechtcheriakova D, Thalhammer T, Pachmann B, Jäger W. Front Pharmacol. 2018 Jul 10;9:742. doi: 10.3389
  20. Huan T, Palermo A, Ivanisevic J1, Rinehart D, Edler D2, Phommavongsay T, Benton HP, Guijas C, Domingo-Almenara X, Warth B3, Siuzdak G. Autonomous Multimodal Metabolomics Data Integration for Comprehensive Pathway Analysis and Systems Biology. Anal Chem. 2018 Jul 17;90(14):8396-8403. doi: 10.1021
  21. Palermo A1, Forsberg EM2, Warth B3, Aisporna AE1, Billings E1, Kuang E2, Benton HP1, Berry D4, Siuzdak G1,5. Fluorinated Gold Nanoparticles for Nanostructure Imaging Mass Spectrometry. ACS Nano. 2018 Jul 24;12(7):6938-6948. doi: 10.1021
  22. Rampler E, Criscuolo A, Zeller M, El Abiead Y, Schoeny H, Hermann G, Sokol E, Cook K, Peake DA, Delanghe B, Koellensperger G. (2018) A Novel Lipidomics Workflow for Improved Human Plasma Identification and Quantification Using RPLC-MSn Methods and Isotope Dilution Strategies. Anal Chem. 2018 May 10.
  23. Hermann G, Schwaiger M, Volejnik P, Koellensperger G.
    13C-labelled yeast as internal standard for LC-MS/MS and LC high resolution MS based amino acid quantification in human plasma. J Pharm Biomed Anal. 2018 Jun 5;155:329-334
  24. Warth B, Raffeiner P, Granados A, Huan T, Fang M, Forsberg EM, Benton HP, Goetz L, Johnson CH, & Siuzdak G (2018) Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy. Cell Chem Biol.
  25. Mayer RL, Schwarzmeier JD, Gerner MC, Bileck A, Mader JC, Meier-Menches SM, Gerner SM, Schmetterer KG, Pukrop T, Reichle A, Slany A, & Gerner C (2018) Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. Mol Cell Proteomics 17(2):290-303.
  26. Jain A, Roustan V, Weckwerth W, & Ebersberger I (2018) Studying AMPK in an Evolutionary Context. Methods Mol Biol 1732:111-142.
  27. Ghatak A, Chaturvedi P, & Weckwerth W (2018) Metabolomics in Plant Stress Physiology. Adv Biochem Eng Biotechnol.
  28. Varshney RK et al. (2017) Pearl millet genome sequence provides a resource to improve agronomic traits in arid environments. Nat Biotechnol 35(10):969-976.
  29. Schwaiger M, Rampler E, Hermann G, Miklos W, Berger W, & Koellensperger G (2017) Anion-Exchange Chromatography Coupled to High-Resolution Mass Spectrometry: A Powerful Tool for Merging Targeted and Non-targeted Metabolomics. Anal Chem 89(14):7667-7674.
  30. Leitner M,  Fragner L,  Danner S,  Holeschofsky N,  Leitner K,  Tischler S,  Doerfler H,  Bachmann G,  Sun X,  Jaeger W,  Kautzky-Willer A,  Weckwerth W (2017) Combined Metabolomic Analysis of Plasma and Urine Reveals AHBA, Tryptophan and Serotonin Metabolism as Potential Risk Factors in Gestational Diabetes Mellitus (GDM). Front Mol Biosci. 2017; 4: 84.
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  31. Bergauer K, Fernandez-Guerra A, Garcia JAL, Sprenger RR, Stepanauskas R, Pachiadaki MG, Jensen ON, Herndl GJ, Organic matter processing by microbial communities throughout the Atlantic water column as revealed by metaproteomics.   Front. Pharmacol., 05 October 2017
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  32. Kerou, M., Offre, P., Valledor, L., Abby, S. S., Melcher, M., Nagler, M., Weckwerth, W.,Schleper, C. (2016).  Proteomics and comparative genomics of Nitrososphaera viennensis reveal the core genome and adaptations of archaeal ammonia oxidizers.  Proc Natl Acad Sci U S A 113, E7937-E46.
  33. Roustan V, Bakhtiari S, Roustan PJ, & Weckwerth W (2017) Quantitative in vivo phosphoproteomics reveals reversible signaling processes during nitrogen starvation and recovery in the biofuel model organism Chlamydomonas reinhardtii. Biotechnol Biofuels 10:280.
  34. Rampler E, Coman C, Hermann G, Sickmann A, Ahrends R, & Koellensperger G (2017) LILY-lipidome isotope labeling of yeast: in vivo synthesis of (13)C labeled reference lipids for quantification by mass spectrometry. Analyst 142(11):1891-1899.
  35. Poschner S, Maier-Salamon A, Zehl M, Wackerlig J, Dobusch D, Pachmann B, Sterlini KL, & Jager W (2017) The Impacts of Genistein and Daidzein on Estrogen Conjugations in Human Breast Cancer Cells: A Targeted Metabolomics Approach. Front Pharmacol 8:699.
  36. Pascual J, Canal MJ, Escandon M, Meijon M, Weckwerth W, & Valledor L (2017) Integrated Physiological, Proteomic, and Metabolomic Analysis of Ultra Violet (UV) Stress Responses and Adaptation Mechanisms in Pinus radiata. Mol Cell Proteomics 16(3):485-501.
  37. Ott E, Kawaguchi Y, Kolbl D, Chaturvedi P, Nakagawa K, Yamagishi A, Weckwerth W, & Milojevic T (2017) Proteometabolomic response of Deinococcus radiodurans exposed to UVC and vacuum conditions: Initial studies prior to the Tanpopo space mission. Plos One 12(12):e0189381.
  38. Linke M et al. (2017) Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Nature immunology 18(3):293-302.
  39. Hoermiller, II, Naegele T, Augustin H, Stutz S, Weckwerth W, & Heyer AG (2017) Subcellular reprogramming of metabolism during cold acclimation in Arabidopsis thaliana. Plant Cell Environ 40(5):602-610.
  40. Ghatak A, Chaturvedi P, Paul P, Agrawal GK, Rakwal R, Kim ST, Weckwerth W, & Gupta R (2017) Proteomics survey of Solanaceae family: Current status and challenges ahead. J Proteomics 169:41-57.
  41. Duszka K, Oresic M, Le May C, Konig J, & Wahli W (2017) PPARgamma Modulates Long Chain Fatty Acid Processing in the Intestinal Epithelium. Int J Mol Sci 18(12).
  42. Wang L, Nagele T, Doerfler H, Fragner L, Chaturvedi P, Nukarinen E, Bellaire A, Huber W, Weiszmann J, Engelmeier D, Ramsak Z, Gruden K, & Weckwerth W (2016) System level analysis of cacao seed ripening reveals a sequential interplay of primary and secondary metabolism leading to polyphenol accumulation and preparation of stress resistance. Plant J 87(3):318-332.
  43. Tosevska A, Moelzer C, Wallner M, Janosec M, Schwarz U, Kern C, Marculescu R, Doberer D, Weckwerth W, & Wagner KH (2016) Longer telomeres in chronic, moderate, unconjugated hyperbilirubinaemia: insights from a human study on Gilbert's Syndrome. Scientific reports 6:22300.
  44. Roustan V, Jain A, Teige M, Ebersberger I, & Weckwerth W (2016) An evolutionary perspective of AMPK-TOR signaling in the three domains of life. J Exp Bot 67(13):3897-3907.
  45. Prezelj N, Covington E, Roitsch T, Gruden K, Fragner L, Weckwerth W, Chersicola M, Vodopivec M, & Dermastia M (2016) Metabolic Consequences of Infection of Grapevine (Vitis vinifera L.) cv. "Modra frankinja" with Flavescence Doree Phytoplasma. Front Plant Sci 7:711.
  46. Pascual J, Alegre S, Nagler M, Escandon M, Annacondia ML, Weckwerth W, Valledor L, & Canal MJ (2016) The variations in the nuclear proteome reveal new transcription factors and mechanisms involved in UV stress response in Pinus radiata. J Proteomics 143:390-400.
  47. Nukarinen E, Nagele T, Pedrotti L, Wurzinger B, Mair A, Landgraf R, Bornke F, Hanson J, Teige M, Baena-Gonzalez E, Droge-Laser W, & Weckwerth W (2016) Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation. Scientific reports 6:31697.
  48. Kogovsek P, Pompe-Novak M, Petek M, Fragner L, Weckwerth W, & Gruden K (2016) Primary Metabolism, Phenylpropanoids and Antioxidant Pathways Are Regulated in Potato as a Response to Potato virus Y Infection.Plos One 11(1):e0146135.
  49. Ghatak A, Chaturvedi P, Nagler M, Roustan V, Lyon D, Bachmann G, Postl W, Schrofl A, Desai N, Varshney RK, & Weckwerth W (2016) Comprehensive tissue-specific proteome analysis of drought stress responses in Pennisetum glaucum (L.) R. Br. (Pearl millet). J Proteomics 143:122-135.
  50. Furuhashi T, Nakamura T, Fragner L, Roustan V, Schon V, & Weckwerth W (2016) Biodiesel and poly-unsaturated fatty acids production from algae and crop plants - a rapid and comprehensive workflow for lipid analysis.Biotechnol J 11(10):1262-1267.
  51. Furtauer L & Nagele T (2016) Approximating the stabilization of cellular metabolism by compartmentalization. Theory Biosci 135(1-2):73-87.
  52. Nagele T, Furtauer L, Nagler M, Weiszmann J, & Weckwerth W (2016) A Strategy for Functional Interpretation of Metabolomic Time Series Data in Context of Metabolic Network Information.  Front Mol Biosci 3:6.
  53. Chaturvedi P, Ghatak A, & Weckwerth W (2016) Pollen proteomics: from stress physiology to developmental priming. Plant Reprod 29(1-2):119-132.
  54. Schuster R, Holzer W, Doerfler H, Weckwerth W, Viernstein H, Okonogi S, & Mueller M (2016) Cajanus cajan–a source of PPARγ activators leading to anti-inflammatory and cytotoxic effects. Food & Function. 7 (9), 3798-3806
  55. Wang L, Fu J, Li M, Fragner L, Weckwerth W, & Yang P (2016) Metabolomic and Proteomic Profiles Reveal the Dynamics of Primary Metabolism during Seed Development of Lotus (Nelumbo nucifera).   Front Plant Sci 7:750.
  56. Meijon M, Feito I, Oravec M, Delatorre C, Weckwerth W, Majada J, & Valledor L (2016) Exploring natural variation of Pinus pinaster Aiton using metabolomics: Is it possible to identify the region of origin of a pine from its metabolites?  Mol Ecol 25(4):959-976.
  57. Kawakatsu T et al. (2016) Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions. Cell 166(2):492-505.
  58. Genomes Consortium. Electronic address mngoaa & Genomes C (2016) 1,135 Genomes Reveal the Global Pattern of Polymorphism in Arabidopsis thaliana. Cell.166(2):481-491
  59. Alegre S, Pascual J, Nagler M, Weckwerth W, Canal MJ, & Valledor L (2016) Dataset of UV induced changes in nuclear proteome obtained by GeLC-Orbitrap/MS in Pinus radiata needles. Data Brief 7:1477-1482.
  60. Stare T, Ramsak Z, Blejec A, Stare K, Turnsek N, Weckwerth W, Wienkoop S, Vodnik D, & Gruden K (2015) Bimodal dynamics of primary metabolism-related responses in tolerant potato-Potato virus Y interaction. BMC Genomics 16:716.
  61. Sun X, Langer B, & Weckwerth W (2015) Challenges of Inversely Estimating Jacobian from Metabolomics Data. Frontiers in bioengineering and biotechnology 3:188.
  62. Nagler M, Nukarinen E, Weckwerth W, & Nagele T (2015) Integrative molecular profiling indicates a central role of transitory starch breakdown in establishing a stable C/N homeostasis during cold acclimation in two natural accessions of Arabidopsis thaliana. BMC Plant Biol 15:284.
  63. Mair A, Pedrotti L, Wurzinger B, Anrather D, Simeunovic A, Weiste C, Valerio C, Dietrich K, Kirchler T, Nagele T, Vicente Carbajosa J, Hanson J, Baena-Gonzalez E, Chaban C, Weckwerth W, Droge-Laser W, & Teige M (2015) SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants.  Elife 4.